Long-term results of cardiac contractility modulation in patients with chronic heart failure

Aim . Evaluate the overall effectiveness of cardiac contractility modulation (CCM) therapy in patients with chronic heart failure various etiology. Methods The study included 61 (NYHA class II-III), ejection fraction 20-40% and narrow QRS <130 ms, who were implanted CCM devices. Depending on etiology failure, ischemic cardiomyopathy prevailed (41 patients). All performed echocardiography, 6-min walk test Minnesota Living Heart Failure questionnaire (MHFLQ). Results. observation period was 25 months. 54 significantly improved left ventricular from 32.2% to 37.6% (?=0.026) volume parameters (left ventricle end systolic 150 137 ml (?=0.034), diastolic 220 201 (?=0.044), reduced NYHA >1 29 (53.7%) (?=0.015), increased 265 343 m (?=0.029), MHFLQ 46.1 35.8 (?=0.042). Non-ischemic associated significant improvement (from 42.7 30.3, ?=0.029) lowering class>1 (83.3%, vs 47.2%, p=0.012) compared group. Conclusion. is safe effective II-III, 20- 40% QRS?130 Results Conclusion ms. class.